OTHER SPECIALIZED TESTS
Autoantibodies to Cytokines: Detection and Functional Assays
Autoantibodies to GMCSF
CCHMC-DIL
Measurement of STAT5 phosphorylation following GMCSF stimulation.
Test code(s): GM-CSF Receptor Stimulation
Measurement of autoantibodies to GMCSF by ELISA.
Test code(s): GMCSF Autoantibody
MONTREAL-SJH
Measures of phosphorylation/dephosphorylation STAT5 (IL2, IL3, IL15, and GMCSF-induced) by flow cytometry.
Test code(s): Étude functionnelle and indicate yourself
NJH-ADL
ELISA measurement of GM-CSF autoantibodies, and reflex testing of P-STAT5 inhibition for positive samples.
Test code(s): GMCSFA
Autoantibodies to Interferon Gamma
MONTREAL-SJH
Measures of phosphorylation of STAT1 in response to gIFN by flow cytometry.
Test code(s): Étude functionnelle and indicate yourself
NJH-ADL
Binding and functional analysis of autoantibodies to IFNg by ELISA and reflex P-STAT1 inhibition assay.
Test code(s): IFNGAB
Molecular Tests (non-Gene Sequencing)
TCR Vb Spectratyping for T Cell Receptor Repertoire Diversity
MAYO-ML
Both visual interpretation of spectratype and diversity ratio information included in report.
Test code(s): TCRVB; #62930
QUEST
T-cell Receptor (TCR) Gamma Gene Rearrangement, PCR. Interrogates the T-cell receptor gamma locus (TCRG) by a PCR method based on the BIOMED-2 consensus.
Test code(s): 90509
T-cell Clonality Panel (TCRG, TCRB), PCR. Interrogates both the T-cell receptor beta (TCRB) locus and the T-cell receptor gamma (TCRG) locus by a PCR method based on the BIOMED-2 consensus.
Test code(s): 91445
T-cell Receptor (TCR) Beta Gene Rearrangement, PCR. Interrogates the T-cell receptor beta locus (TCRB) by a PCR method based on the BIOMED-2 consensus.
Test code(s): 91446
TREC Quantitation Relative to CD3 T Cell Count
MAYO-ML
TREC quantitatoin reported as copies per million CD3+ T cells.
Test code(s): TREC; #87959
Specialized Serologic Testing for Vaccine Response Evaluation (not including routine vaccine titers)
Functional Antibody Analysis
VIRACOR
Functional Antibody Analysis- Pneumococcal Avidity. A modification of the standard pneumococcal assay, using varying concentrations of ammonium thiocyanate. Bound antibodies are detected with an antibody that recognizes human IgG. The IgG antibody concentration is calculated using a standard curve referenced to WHO standard serum 89SF. The avidity is calculated based on binding with various concentrations of thiocyanate. Multiple Panels available with varying number of serotypes:
Test code(s): 401734, 401846, 401839, and 4017345
Therapeutic Monitoring Lymphocyte Depletion
Therapeutic Monitoring Following Alemtuzumab (Alemtuzumab Levels)
CCHMC-DIL
Flow based assay to measure alemtuzumab levels in whole blood.
Test code(s): Alemtuzumab Level
Therapeutic Monitoring Following Alemtuzumab (CD52 Expression)
CCHMC-DIL
Quantifies CD52 on T cells, NK cells, B cells, monocytes.
Test code(s): CD52 Expression
