THURSDAY, MAY 1

 

8:00am – 1:30pm | Pre-Conference Education Day

8:00 - 8:30AM      The Post-Thymectomy State and T Cells, Sarah Nicholas, MD, Baylor College of Medicine

8:30 - 9:00AM      Vaccination Post CAR-T Cell Therapy, Mike D. Keller, MD, FCIS, Children's National Hospital

9:00 - 9:30AM      Solid Organ Transplant/Postcardiac Transplantation and Management of the Iatrogenically-Induced Immune Deficient State, Lauren M. Gunderman, MD, University of Washington School of Medicine and Seattle Children's Hospital

9:30 – 10:00AM    Assessment of Immune Function in Patients on Immunomodulator/ Immunosuppressive Therapies, Vijaya Knight, MD, PhD, FCIS,University of Colorado School of Medicine, Aurora, CO

10:00 – 10:30AM BREAK

10:30 - 11:00 AM        Transition of Care from Peds to Adult for IEI Patients, Catherine Biggs, MSc, MD, BSc, BC Children's Hospital

11:00 - 11:30 AM         Building an Immunology Practice from Scratch, Nick L. Hartog, MD, FAAAAI, Helen DeVos Children's Hospital

11:30 - 12:00 PM         IEI Hiding Among Patients with Atopy, Josh D. Milner, MD, FCIS, Columbia University Medical Center

12:00 - 12:30 PM         Infection Prevention/Prophylaxis in IEIs, Alexandra F. Freeman, MD, NIH, NIAID, Bethesda, MD

 

12:30 – 1:30PM | BOXED LUNCHES AVAILABLE – PRE-PURCHASE AND TICKET REQUIRED

 

12:45 – 1:45PM | First Time Attendee Event

 

2:00 – 2:15pm | Opening and Welcome

 Elie Haddad, CIS President

 

2:15 – 3:55pm | Plenary #1: Exceptional Abstracts

2:15 - 2:35 PM ORAL ABSTRACT: PPM1D-mediated regulation of the DNA Damage Repair pathway in NK cell development and migration - Ana Esteve-Sole, PhD, Department of Laboratory Medicine, Clinical Center, National Institutes of Health

2:35 - 2:55 PM ORAL ABSTRACT: Massively scalable generation, discovery, and clinical (re-)classification of inborn errors of immunity using cutting-edge genome engineering, Zachary Walsh, BA, Columbia  University

2:55 - 3:15 PM ORAL ABSTRACT: Allelic bias contributes to incomplete penetrance of NK cell deficiency, Seungmae Seo, PhD, University of Maryland Eastern Shore

3:15 - 3:35 PM ORAL ABSTRACT: Elevated CD38 expression and a concomitant reduction in NAD+ levels underlie CD8+ T cell dysfunction in STAT1 GOF, Andrea A. Mauracher, MD, PhD, Children’s Hospital of Philadelphia

3:35 - 3:55 PM ORAL ABSTRACT: Enhancer hijacking of the IGH locus as a novel genetic mechanism of an inborn error of immunity leading to invasive Streptococcus pneumoniae infection due to antibody deficiency, Joshua Tobin, BS, Division of Rheuma

 

3:55 – 4:15pm | Break

 

4:15 – 5:45pm | Plenary #2: Immunometabolism

4:15 - 4:35 PM      Metabolic impacts of IEI genes and immune impacts of IEM genes, TBD

4:35 - 4:55 PM      Caring for patients with diseases that impact mTOR and RAS signaling V. Koneti Rao, MD, FRCPA National Institute of Allergy and Infectious Diseases, Bethesda, MD

4:55 - 5:15 PM      Interplay amongst metabolic, antigenic, cytokine and hormonal factors in T cell differentiation Naomi Taylor, MD, PhD National Cancer Institute, Bethesda, MD

5:15 - 5:35 PM       Metabolic reprogramming of T cell fate, with a focus on mTOR Hongbo Chi, PhD St. Jude Children’s Research Hospital, Memphis, TN

5:35 – 5:50 PM       Question & Answer Time with All Speakers

 

5:50 – 6:50pm | Robert A. Good Lecture

Topic TBD
Michail S. Lionakis, MD, ScD
National Institutes of Health (NIH), Bethesda, MD

 

7:30 – 10:30pm | Foundation Event Off Site at the Union Trust

 

FRIDAY, MAY 2

 

7:00 – 8:00am | Corporate Breakfast Symposium "Bridging the Gap: How to Support Adherence in Young Adults with PIDs"
                             Sponsored By: 

 

7:00 – 8:00am | Breakfast for all Attendees

 

8:00 – 9:00am | William Shearer Lecture

Topic TBD
Kathleen E. Sullivan, MD, PhD
Children's Hospital of Philadelphia, Philadelphia, PA

9:00 – 9:45am | Diversity and Inclusion Lecture

 

9:45 – 10:15am | Break

 

9:45 – 10:15am | Lightning Poster Session #1

9:45 - 9:51 AM           Validation of an Interferon type I score test on the Nanostring nCounter platform, Samuel Chiang, PhD, Cincinnati Children’s Hospital

9:51 - 9:57 AM           Unravelling enigmatic IgE expressing B cells by studying patients with monogenic atopic disorders, Stuart Tangye, PhD, Garvan Institute

9:57 - 10:03 AM         Two to Six Year Clinical Outcomes Prior to Treatment with Cultured Thymus Tissue Implantation in Children with Congenital Athymia, Benjamin Stewart-Bates, DO, Duke University

10:03 - 10:09 AM       Serum proteome of APECED patients reveals heterogeneity in autoimmune responses associated with clinical outcomes, Iivo Hetemaki, MD, PhD, National Institutes of Health

10:09 - 10:15 AM       Atypical B cell expansion and immune dysregulation are promoted by an inflammatory milieu in STAT1GOF and STAT3DN patients, Zixiao (Annie) An, BA, National Institutes of Health

 

10:15 – 11:45am | Plenary Session #3: Secondary Immunodeficiencies

10:15 - 10:35 AM            Use of CPT in IEI Patients With Chronic Viral Infections, Irene Cortese, MD, PhD, National Institutes of Health

10:35 - 10:55 AM            Mechanisms of autoimmune complications of CPT, Melissa G. Lechner, MD, PhD, UCLA David Geffen School of Medicine

10:55 - 11:15 AM            Infections in BTK inhibitor-treated patients, Tobias Hohl, MD, PhD, Memorial Sloan Kettering Cancer Center

11:15 - 11:25 AM            ORAL ABSTRACT: Anti-cytokine Autoantibodies in Inborn Errors of Immunity with Immune dysregulation, Su-Wan, Bianca Chan, MD, KK Women's and Children's Hospital, Singapore

11:25 – 11:45 AM           Question & Answer Time with All Speakers

 

11:45 – 2:30pm | Exhibit Hall Open

 

12:00 – 1:00pm | Lunch

 

12:30 – 1:30pm |   Corporate Lunch Symposium: Tailoring Approaches to Primary
                               Immunodeficiency: Case studies from experts in diagnosis and
                               treatment focused on optimizing the patient experience

   Join us for an engaging session featuring two physicians who are experts in primary
   immunodeficiency (PI). Through detailed case reviews of patients of various ages,
   they will present insights in diagnosing and treating PI, offering valuable clinical
   observations and a subcutaneous treatment option.

   Sponsored by:

 

12:30 – 2:00pm | Investigators of CIS Luncheon Session

 

1:30 – 2:30pm | Friday Poster Session

 

2:30 – 4:00pm | Plenary Session #4: Tales from the Listserv

Chairs: Elie Haddad, Eric Allenspach, Kelli Williams

2:30 – 3:00PM                 Case #1: Jay Jin, MD, PhD, Indiana University School of Medicine

3:00 – 3:30PM                 Case #2: Neema Izadi, MD, MS, Children's Hospital of Los Angeles, University of Southern California

3:30 – 4:00PM                 Case #3: Jacques G. Rivière, Vall dHebron University Hospital

 

4:00 – 4:30pm | Break

 

4:30 – 6:00pm | Plenary Session #5: How to Approach CVID

What is CVID?, Klaus Warnatz, MD, University of Freiburg

Innovative Diagnostics of Complicated CVID,
Jocelyn R. Farmer, MD, PhD, Beth Israel Lahey Health

Pathogenesis and Management of GI Disease in CVID,
Hsi-En Ho, MD, Icahn School of Medicine at Mount Sinai

Role of Genetics and Potential Monogenic Disorders Presenting Like CVID,
Xiao P. Peng, MD, PhD, Montefiore Einstein and Albert Einstein College of Medicine

 

6:00 – 7:00pm | ECI Reception

 

7:00 – 8:30pm | Summer School Reunion Dinner

 

6:00 – 7:30pm | Corporate Dinner Symposium
                               Sponsored by:

 

 

SATURDAY, MAY 3

 

7:00 – 8:00am | Corporate Breakfast Symposium “Personalizing Ig Therapy in Patients With PI”
                               Sponsored by:  

 

7:00 – 8:00am | Breakfast for all Attendees

 

7:00 – 8:00am | CIS Business Meeting

 

8:00 – 9:00am | Fahey/Rose Founders Lecture

Human cross-species immune response to xenografts 

Robert Montgomery, MD, DPhil
NYU Langone Health, New York, NY

 

9:00 – 10:30am | Plenary #6: Non Genetic Modifiers of Immune Responses

9:00  - 9:20 AM        Sexual hormones, Petter Brodin, MD, PhD,  Karolinska Institutet

9:40 - 9:50 AM         ORAL ABSTRACT: Thymoma-associated autoimmunity is Th1 driven and can be ameliorated with baricitinib, Iivo M. Hetemäki, MD, PhD, National Institutes of Health

9:50 - 10:00 AM       ORAL ABSTRACT: Autoantibodies in 22q11.2 deletion syndrome with and without schizophrenia, Samantha Y. Starkey, MD

 

10:30 – 11:00am | Break

 

10:30 – 11:00am | Lightning Poster Session #2

10:30 – 10:36 AM           Dissecting the Glycolytic Requirements of Human T cells via G6PC3 Deficiency, Xin Zhen, BSc, Vanderbilt University

10:36 - 10:42 AM            DOCK8 Deficiency: extended clinical phenotypes and the impact of somatic reversions, Alexandra Freeman, MD, NIH

10:42 - 10:48 AM            Endophilin-A2 deficiency impairs antibody production in humans, Cybel Mehawej, PhD, Lebanese American University

10:48 - 10:54 AM            Evaluating Transition and Survival in Adolescents and Young Adults with Inborn Errors of Immunity, Gail Tan, MD, Baylor College of Medicine Allergy and Immunology Fellowship

10:54 AM - 11:00 AM     Human heterozygous TBK1 variations lead to Autoinflammation, Yemsratch Akalu, PhD, Columbia University

 

11:00am – 12:30pm | Plenary #7: Needs Across the Spectrum of Age in IEIs

11:00 - 11:20 AM        X-linked agammagloblinemia - outcomes throughout the life course, Vivian P. Hernandez-Trujillo, MD, Allergy and Immunology Care Center of South Florida

11:20 - 11:40 AM         Late complications of SCID,  Jennifer Heimall, MD, The Children's Hospital of Philadelphia, Philadelphia, PA

11:40 AM - 12:00 PM   Pregnancy in IEI, Caroline Charlier-Woerther, MD, PhD, Institut Pasteur

12:00 – 12:10 PM            ORAL ABSTRACT Identification of Serum Prognostic Biomarkers for 5-year CVIDc Disease Progression, Hsi-En Ho, MD, Icahn School of Medicine at Mount Sinai

12:10 – 12:30 PM           Question & Answer Time with All Speakers

 

12:30 – 2:30pm | Lunch/Exhibit Hall Open

 

12:30 – 1:30pm | Corporate Lunch Symposium
                                 Sponsored by:

 

12:30 – 1:30pm | Early Career Immunologist Luncheon

 

1:30 – 2:30pm | Saturday Poster Session

 

2:30 – 4:00pm | Plenary #8: GI Manifestations

2:30  - 2:50 PM         Clinical approach to early-onset IBD, Judith R. Kelsen, MD, Children's Hospital of Philadelphia

2:50 - 3:10 PM          Microbiota and immunity, Marlies Meisel, PhD, University of Pittsburgh

3:10 - 3:30 PM           Immune Deficiency in IBD, Aleixo Muise, MD, PhD, University of Toronto

3:30 - 3:40 PM           ORAL ABSTRACT LTβR deficiency causes lymph node aplasia and impaired B-cell differentiation, Kaan Boztug, MD, LBI for Rare and Undiagnosed Diseases & St. Anna CCRI

3:40 – 4:00 PM                Question & Answer Time with All Speakers

 

4:00 – 4:45pm | Presidential Award Lecture

 

5:00– 6:00pm | Closing Reception

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SUNDAY, MAY 4

 

7:00 – 8:00am | Breakfast for all Attendees

 

8:00 – 9:30am | Plenary #9: How I Manage

8:00 - 8:25 AM                 Autoimmune Cytopenias, Shanmuganathan Chandrakasan, MD, FCIS, Emory University School of Medicine, Children's Healthcare of Atlanta

8:25 - 8:50 AM                 Idiopathic CD4 Lymphopenia Irini Sereti, MD, MHS, NIAID, NIH

8:50 - 9:15 AM                 HLH vs. MAS, Scott W. Canna, MD, Children's Hospital of Philadelphia

9:15 - 9:25 AM                 ORAL ABSTRACT Treatment of autosomal recessive interleukin-7 deficiency with NT-I7 (efineptakin alfa), long-acting recombinant human interleukin-7: an expanded access protocol, Derek MacMath, MD, National Institutes of Health, National Institute of Allergy and Infectious Diseases

 

9:30 – 9:45am | Break

 

9:45 – 11:30 | Plenary #10: Late Breaking Advances in IEIs

9:45 - 10:00 AM              ORAL ABSTRACT Defects in B cell differentiation and antibody production due to biallelic TANK mutation, Janet G. Markle, PhD, Vanderbilt University

10:00 - 10:15 AM            ORAL ABSTRACT BCMA deficiency as a novel cause of common variable immunodeficiency, Basak Kayaoglu, PhD,  National Institute of Allergy and Infectious Diseases (NIAID)

10:15 - 10:30 AM            ORAL ABSTRACT Deep sequencing reveals somatic mosaicism in genes relevant to genetic errors of immunity in a cohort of patients with immune dysregulation, Elizabeth G. Schmitz, BS, Washington University in St. Louis

10:30 - 10:45 AM            ORAL ABSTRACT EML4 deficiency causes alveolar macrophage dysfunction and interstitial lung disease, Elissa Deenick, PhD, Garvan Institute of Medical Research/UNSW Sydney

 

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