Thursday, March 31

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8:00am - 2:00pm | Pre-Conference Education Day: Clinical Use of Biologicals: From Small Molecules to Big Antibodies

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2:15pm - 2:30pm | Opening and Welcome

Sergio Rosenzweig, MD, PhD
CIS President

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2:30pm - 3:50pm | Plenary Session #1: Notable Abstracts

Moderators: Troy Torgerson, MD, PhD & Hana Niebur, MD

2:30pm - 2:45pm The contribution of mosaic variants to molecular diagnosis in subjects with immune disorders - Magdalena A. Walkiewicz, PhD

2:45pm - 3:00pm The effects of Microbiome and Immunoglobulin Therapy on Immune Dysregulation in Common Variable Immunodeficiency - Joud Hajjar, MD, MS

3:00pm - 3:15pm Who's your data? Primary immune deficiency differential diagnosis prediction via machine learning and data mining of the USIDNET registry - Saul O. Lugo Reyes, MD, MS

3:15pm - 3:30pm Reduced mTORC1 signal in patients with dominant negative STAT3 mutations - Jacob Y. Edinger, BS

3:30pm - 3:45pm PLCG2 variants observed in human immune dysregulation alter B cell activity - Michael Ombrello, MD

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3:50pm - 4:05pm | BREAK

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4:05pm - 5:45pm | Plenary Session #2: Severe COVID-19 and MIS-C: Genetic Susceptibilities and Prevention in IEI

Moderators: Luigi Notarangelo, MD & Ben Prince, MD

4:05pm - 4:35pm Development of SARS-CoV-2 neutralizing nanobodies - Jianliang Xu, PhD

4:35pm - 5:05pm COVID-19 Vaccine Responses in IEIs - Luigi Notarangelo, MD

5:05pm - 5:35pm Genetic susceptibility to MIS-C - Shen-Ying Zhang, MD, PhD

5:35pm - 5:45pm ABSTRACT
Proteomic profiling reveals restricted heavy chain subfamily expression of vaccine-elicited SARS-CoV-2 spike-specific antibodies in patients with primary antibody deficiencies - Alexander Troelnikov, MBBS, BMedSci (Hons)

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5:45pm - 6:00pm | BREAK

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6:00pm - 7:00pm | Robert A. Good Lecture

Moderator: Tom Fleisher, MD & Nikita Raje, MD, MSc

Hepatitis C: The End of the Beginning and Possibly The Beginning of the End
Harvey Alter, MD

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7:00pm - 8:30pm | CIS Foundation Happy Hour: Raise a Glass

*Separate ticket purchase required*

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Friday, April 1

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7:00am - 8:00am | 101 Session: Genomics and Genetics

*Separate Registration Required*

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8:00am – 9:45am | Plenary Session #3: The Future of Gene Correction in PIRD

Moderators: Claire Booth, MBBS, MRCPCH, MSc and Sung-Yun Pai, MD

8:00am - 8:30am New Approaches to Gene Correction for Inborn Errors of Immunity - Claire Booth, MBBS, MRCPCH, MSc

8:30am - 9:00am Gene Therapy for IPEX Syndrome: Present and Future - Rosa Bacchetta, MD

9:00am - 9:30am Advanced Genetic Engineering of Hematopoiesis for the Treatment of Immune Deficiencies - Pietro Genovese, PhD

9:30am - 9:45am ABSTRACT
Epigenetic quantification of the Treg specific FOXP3 regulatory region (TSDR) can assist with variant classification and denote disease severity in IPEX syndrome - Rebecca C. Wyatt, PhD

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9:45am – 10:15am | BREAK

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10:15am – 11:45am | Plenary Session #4: Precision Medicine for Hyperinflammatory Disorders

Moderators: Scott Canna, MD & Talal Mousallem, MD

10:15am - 10:45am Novel insights to genetics and immunopathology of HLH/MAS - Yenan Bryceson, PhD

10:45am - 11:15am Update on Novel Therapies for HLH/MAS: A Focus on Cytokine Inhibition - Kim Nichols, MD

11:15am - 11:30am Multi-disciplinary management of HLH/MAS - Lauren Henderson, MD

11:30am - 11:45am ABSTRACT
Phase 3 Placebo-Controlled, Randomized Clinical Trial Outcomes of PI3K Delta Inhibitor Leniolisib in Patients with Activated PI3K Delta Syndrome (APDS/PASLI) - V. Koneti Rao, MD, FRCPA

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11:45am - 2:00pm | LUNCH

11:45am - 12:45pm Lunch Symposium

ADA-SCID: Disease Management & Treatment Landscape Symposium
 

Sponsored by:

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12:30pm - 1:00pm Lightning Poster Presentations

1:00pm - 2:00pm Friday Poster Session

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2:00pm - 3:00pm | Plenary Session #5: Editors Roundtable

Moderators: Elie Haddad, MD, PhD & Troy Torgerson, MD, PhD

Panelists: Zuhair Ballas, Vincent Bonagura, Jean Laurent-Casanova

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3:00pm - 4:30pm | Plenary Session #6: Immunology and Infectious Disease Around the World

Moderators: Jenna Bergerson, MD & Cecila Poli, MD, PhD

3:00pm - 3:20pm Changing Landscape of IEI in India: A decade of progress - Sudhir Gupta, MD, PhD, MACP

3:20pm - 3:40pm Implementation of Newborn Screening for IEI in Brazil - Antonio Condino-Neto, MD, PhD

3:40pm - 4:00pm Looking for PIDs within African endemic diseases - Nahla Erwa, MBBS

4:00pm - 4:20pm PID management in Israel and the Palestinian Authority territories: Doing our best in a conflictive scenario - Raz Somech, MD, PhD

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4:30pm - 5:00pm | BREAK

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5:00pm - 6:00pm | CIS Rose/Fahey Lecture

Moderators: Roshini Abraham, PhD & Melissa Gans, MD

Speaker: Michael Hershfield, MD

6:00pm - 8:00pm | Diversity & Inclusion Session and Reception

Organized by the Diversity & Inclusion and Women in Clinical Immunology Sciences Committees

"Professional Work in a 'Post-Racial' Era: Black Health Care Workers in the New Economy"

Adia Harvey Wingfield
Mary Tileston Hemenway Professor of Arts & Sciences,
​Associate Dean for Faculty Development, and Professor of Sociology

7:30pm - 9:00pm. |   Dinner Symposium

Hiding on the X: Rethinking Perceptions of Carriers of X-Linked CGD

Click here to register for the dinner symposium

 

 

Sponsored by:

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Saturday, April 2

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6:45am - 7:45am | Breakfast Symposium

Patient Case-Based Panel Discussion: The Pursuit of Reliable Infection Protection in PIDD

Sponsored by:

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7:00am - 8:00am | 101 Session: Immunomodulators and Biologics

*Separate Registration Required*

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8:00am - 9:45am | Plenary Session #7: Oh No, Secondary Immune Deficiencies and Dysregulation!

Moderator: Sarah Nicholas, MD and Lisa Forbes-Satter, MD

8:00am - 8:30am CAR-T Hyperinflammation and HLH - Dave Teachey, MD

8:30am - 9:00am Checkpoint Inhibitors - Terri Laufer, MD

9:00am - 9:30am Solid Organ Transplant Rejection and Immunodeficiency: a fine balance - Sarah Nicholas, MD

9:30am - 9:45am ABSTRACT
Perturbation of adaptive immune responses to SARS-CoV-2 infection - Ottavia M. Delmonte, MD, PhD

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9:45am - 11:15am | Plenary Session #8: Bringing Research Testing to Clinical Implementation

Moderators: Emily Mace, PhD & Rebecca Marsh, MD

9:45am - 10:00am CLIA, CAP and other acronyms: Regulatory oversight in the clinical diagnostic laboratory - Tom Fleisher, MD

10:00am-10:15am - Ushering in the genomic era in the clinical laboratory- Ivan Chinn, MD

10:15am-10:30am - What you wanted to know but didn’t about development, validation and implementation of clinical immunology tests - Sam Chiang, PhD

10:30am - 10:45am - Functional flow cytometry in the clinical lab: Shapeshifting to meet the regulatory challenges and clinical needs - Roshini Abraham, PhD

10:45am - 11:15am - Round Table Discussion

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11:15am - 11:45am | BREAK

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11:45am - 12:15pm | Presidential Award Lecture

Moderator: Elie Haddad, MD, PhD & Carolyn Baloh, MD

The Host, the Pathogen and the Strategies
Kate Sullivan, MD, PhD

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12:15pm - 12:45pm | CIS Business Meeting

*CIS Members Only*

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12:30pm - 2:30pm | Lunch/Exhibit Hall Open

12:30pm - 1:30pm ECI Lunch/Career Development Panel

Troy Torgerson, MD, PhD - Representing a career in industry
Mike Keller, MD - Representing a career in research
Jennifer Heimall, MD - Representing program leadership/Fellowship Program Director

12:45pm - 1:45pm Lunch Symposium

Challenges Associated With Respiratory Viral Infections in Patients with Primary Immunodeficiency: An Expert Discussion

Sponsored by:

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1:00pm - 1:30pm Saturday Lightning Poster Presentations

1:30pm - 2:30pm Poster Session II: Saturday Presenters

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2:30pm - 4:00pm | Plenary Session #9: Tales from the Listserv

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4:00pm - 4:30pm | BREAK

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4:30pm - 5:30pm | William Shearer Lecture

Moderators: Lisa Forbes-Satter, MD and Jenny Shin, MD, PhD

History of CVID as a non-genetic clinical syndrome evolving to single gene diseases
Charlotte Cunningham-Rundles, MD, PhD

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5:45pm - 7:00pm | CLOSING RECEPTION

*Complimentary with Annual Meeting Registration*

7:30pm - 9:00pm  |  Dinner Symposium

Management of Congenital Athymia: A Case-Based Approach

Sponsored by:

To RSVP for the event and view more information click here

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Sunday, April 3

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7:00am - 8:00am | Plenary Session #10 PIDs with Susceptibility to Particular Infectious Disease Agents

Moderators: Steve Holland, MD and Niraj Patel, MS, MD

7:00am - 7:30am - Modeling genetics of human disease susceptibility - Nadia Rosenthal

7:30am - 8:00am - Coccidioidomycosis- Steve Holland, MD

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8:00am - 9:00am | Plenary Session #11: Hot New Defects in IEIs

Moderators: Steve Holland, MD & Harry "Adrian" Lesmana

9:00am - 9:30am - cREL - Anne Puel

9:30am - 9:45am - A surface homophilic receptor LY9 governs IFN-γ and IL-17/22 immunity to protect humans from tuberculosis and candidiasis - Masato Ogishi

9:45am - 10:00am - Gene Expression Profiling and Signaling Pathway Analysis of Tolerance in an IL-7R- SCID Patient Following Bilateral Orthotopic Lung Transplant and Bone Marrow Transplant from the Same Cadaveric Donor - Paul Szabolcs

9:00am - 9:20am | Break

9:20am - 11:05am | Plenary Session #11: Hot New Defects in IEIs Part 2

Moderators: Steve Holland, MD & Harry "Adrian" Lesmana

9:20am - 9:35am - Identification of Germline Monoallelic Mutations in IKZF2 in Patients with Immune Dysregulation - Daniel Mayr

9:35am - 9:50am - ARPC5 deficiency, a novel actinopathy presenting with Job’s syndrome /STAT3 GOF-like features and dissecting IL-6 classical and trans-signaling - Cristiane Nunes dos Santos

9:50am - 10:05am - Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy - Stuart Turvey

10:05am - 10:20am - TCF3 haploinsufficiency disease: a question of gene dosage and penetrance - Brigette Boast

10:20am - 10:35am - Breaking of Immune Tolerance in Down Syndrome: A Triad of Cytokines, Activated T cells and Extrafollicular B Cells - Louise Malle

10:35am - 10:50am - Germline Gain-Of-Function Variants in JAK1 Lead to a Spectrum of Autoinflammation - Michael Espino

10:50am - 11:05am - COVID-19 Vaccine Usage, Effectiveness, and Safety in Patients with Inborn Errors of Immunity: A USIDNET Registry Study - John McDonnell